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Disease/Disorder

Definition

Lateral epicondylosis (LE) is a common, painful condition affecting the lateral region of the elbow. This condition was previously known by many different names, including tennis elbow and lateral epicondylitis. Evidence indicates that the condition affects the common extensor tendon at the elbow and that the pathophysiologic process is more often tendinosis instead of tendinitis (since tendinitis is usually seen in the acute phases).1,2

Etiology

LE is most often a chronic degenerative process involving the origin of the common extensor tendon. Injury occurs from accumulation of microtrauma due to repetitive stress, resulting in tendinosis. If left untreated, tendinosis may lead to partial tears and progress to full-thickness tears, particularly in the setting of an acute overload injury.1

Epidemiology including risk factors and primary prevention

LE is the most common cause of lateral elbow pain. It frequently occurs in the dominant upper extremity of middle-aged adults. Its annual incidence is estimated at 1% to 3% of the general population.3,4

Despite the common term “tennis elbow,” only 10% of cases of LE are secondary to racket sports.5 Intrinsic risk factors include female gender, type 2 diabetes mellitus, obesity, and biomechanical malalignments.6,7,8 Chronic hyperglycemia, advanced glycation end products, and insulin resistance have been shown to contribute to the development of diabetic tendinopathy.9 Extrinsic risk factors include current and former smoking, heavy manual labor occupation, and repetitive tasks involving wrist extension and forearm supination.6,7,10,11,46 More specifically, work tasks requiring handling of 1-kg tools or 20-kg loads, lifting for ≥3% of time, or repetitive stressful movements >2 hours a day have been associated with LE.10,11

Patho-anatomy/physiology

The anterior aspect of the lateral epicondyle and supracondylar ridge forms the origin of the conjoined extensor tendon, incorporating the extensor carpi radialis brevis (ECRB), extensor digitorum communis (EDC), extensor digiti minimi (EDM), and extensor carpi ulnaris (ECU). Repetitive contraction of the forearm musculature yields microtearing with subsequent tendinosis. Poor vascularity of the ERCB tendon contributes to tendinosis, which is typically the initial site of injury.5

Histopathologically, tendinosis is characterized by a degenerative process marked by disorganized tendon fibers, with occasional local necrosis, calcification, or neovascularization. Tendon tearing can follow due to degradation of the tendon fibers.1,2

Another important concept to consider when discussing tendinosis is the amount and type of load placed on the tendon. Tendinosis arises due to an excessive imbalance of tendon load. However, some tensile mechanical loading (as opposed to immobilization) is essential for tendon integrity and strength as this results in upregulation of collagen expression and increased synthesis of collagen protein. This is important to recognize in the plan of treatment as there is a narrow range of ideal strain that stimulates an anabolic effect in tendon tissue.12,13,14

Recent studies also suggest LE may be a manifestation of elbow instability. There is close proximity of the ECRB and the nearby static stabilizers of the lateral elbow, the radial collateral ligament (RCL), and the lateral ulnar collateral ligament (LUCL). Failure of these static stabilizers is thought to result in ECRB overloading during dynamic movement. RCL and LUCL abnormality is the most common accompanying finding with LE on ultrasound and MRI. Furthermore, the degree of RCL and LUCL injury positively correlates with severity of disease and outcomes.15,16 

Disease progression including natural history, disease phases or stages, disease trajectory (clinical features and presentation over time)

Traditionally, it was thought that patients with LE would improve over time without intervention. While it is true that 80-90% of patients with LE report improvement at one year with conservative treatment, not all patients will improve without intervention.17 Fortunately, less than 11% of patients ever require surgical intervention.18 Poor prognostic factors for conservative treatment include manual labor, dominant arm involvement, high pain perception, poor coping mechanisms, and the presence of an associated lateral elbow ligament injury.15,16,19,20

Specific secondary or associated conditions and complications

LE can be associated with a partial-thickness tear or a full-thickness tendon rupture, which can be complications of rapid or forceful eccentric strain in the setting of advanced tendinopathy.1,2 Posterior interosseous nerve (PIN, also known as the deep branch of the radial nerve) compression or entrapment most commonly occurs as it passes through the Arcade of Frohse between the supinator muscle and is another possible complication. This can occur due to fibrous thickening of the periosteum and the interstitial connective tissue at this region. Repetitive action of the extensor and supinator muscle groups may also cause repeated microtrauma to the nerve.1,2 This results in weakness of the wrist and finger extensors, but no sensory disturbances. Despite a similar clinical presentation, radial tunnel syndrome (RTS) should be considered a different clinical entity. With RTS, compression of the PIN is milder and can occur more proximal near the point of bifurcation from the superficial sensory branch. Distinction can be made clinically with RTS which primarily presents with pain in the proximal dorsolateral forearm, possible sensory disturbance along the distal lateral forearm and the dorsal hand, but without remarkable weakness in finger extension.21,22

Essentials of Assessment

History

A typical patient history often includes a description of pain over the lateral aspect of the elbow, anterior to the lateral epicondyle. This pain is typically sharp; it may radiate distally, exacerbated by activities involving gripping and wrist extension.6,23 Aggravating and relieving factors should be identified, as well as motor weakness that may signify nerve involvement. One must also ask about pertinent past social and medical history, such as manual labor occupation, smoking use, and diabetes.

Physical examination

Inspection of the involved wrist, elbow, shoulder, and cervical spine should be performed. Tenderness to palpation occurs 2-5 mm distal to the lateral epicondyle. RTS can also cause tenderness to palpation but usually 4-5cm distal to the lateral epicondyle. Elbow range of motion (ROM) is often unaffected. With LE, pain can occur with supination, wrist extension, and finger extension strength testing but true weakness is not observed. In comparison, PIN compression can result in weakness in wrist and finger extension as well as radial deviation with attempted wrist extension.21 Special tests for LE may reproduce pain, including resisted extension of the wrist (Cozen’s Test), resisted extension of the third digit of the hand (Maudsley’s test), passive stretching of the wrist extensor muscles (Mill’s Test), or lifting a chair with fully extended elbows (Chair Test).6,23 A positive Tinel’s near the supinator muscle mass raises concern for RTS.22 If considering cervical radiculopathy, examination with focused attention on upper extremity strength, reflexes, evaluation for upper motor neuron signs, sensation, and special tests should be performed. Special tests for cervical radiculopathy include the Spurling’s test and Bakody’s test.

Functional assessment

Activities of daily living or work tasks may be impaired due to pain. A thorough appraisal of the patient’s ROM, grip strength, and function may be necessary. Patients with biomechanical abnormalities may require an ergonomic evaluation to prevent further damage and worsening of symptoms. Athletes presenting with LE require a careful assessment of equipment, warm-up regimen, and technique.

Laboratory studies

Laboratory studies are rarely necessary. If multiple joints are involved or an infectious process is suspected, a further work-up may be indicated.

Imaging

Plain radiographs may be utilized to rule out bony pathology and to assess anatomical alignment. Calcifications within the extensor muscle mass origin can also be seen.2,23

Magnetic resonance imaging (MRI) may demonstrate changes consistent with tendinosis and/or tears. An MRI can be useful in ruling out intra-articular and surrounding soft tissue processes, although MRI is not routinely recommended given the cost and poor correlation with clinical severity.

Musculoskeletal ultrasound is now considered ideal for initial clinical diagnostic investigation as it can evaluate for structural tendon changes, bone irregularities, calcific deposits, and neo-vascularization. However, limitations may exist due to availability of equipment and inter-operator variability.23-25

Both ultrasound and MRI can also assess for the presence of an associated lateral elbow ligament tear and large intrasubstance tears, which can predict a poorer outcome with non-operative treatment.15,16,42

Supplemental assessment tools

Electrodiagnostic studies will be normal in isolated cases of LE. However, if there is involvement of the PIN, motor nerve conduction studies may demonstrate slowed conduction velocity across the elbow, prolonged distal latency, and reduced amplitude. Superficial radial nerve SNAP is usually normal. EMG can show findings of acute denervation in PIN innervated muscles (ECRB, supinator, EDC, and ECU) and also evaluate for a cervical radiculopathy if that is a clinical concern.

Supplemental assessment tools include the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire. PRTEE is a useful tool that allows patients to rate their levels of pain and disability, and DASH can be utilized to evaluate the outcomes of conservative treatments, as well as surgical treatments for LE.20,26

Environmental

One should consider modifying work or sport specific tasks such as repetitive hammer use, machinery use, and proper technique in tennis racket swings to minimize repetitive strain on the extensor elbow tendons. Reducing tennis racket string tension and increasing racket grip diameter may help.

Social role and social support system

If the pain is so severe that the afflicted patient cannot work, this may become financially burdensome. Collaboration with occupational health and social support systems should be encouraged early in such circumstances.

Professional issues

Returning to one’s sport or occupation requires that the repetitive strenuous forces to the affected area be modified and that activity specific exercises be initiated. Patients may need ergonomic modifications, including workstation adjustments and postural retraining.

Rehabilitation Management and Treatments

Available or current treatment guidelines

Different rehabilitation techniques and treatments for LE are currently under investigation. To date, there are no standardized treatment guidelines for LE, although some general principles should be considered.10,11,18,27,28

At different disease stages

Treatment should be tailored to a patient’s needs and desired activities. Modifiable risks factors should be addressed including obesity, smoking cessation, and diabetes control. The initial focus is primarily on symptomatic relief. Acute exacerbations can be managed by activity modification to the involved extremity. A forearm counter-force brace or a wrist extension splint can sometimes be utilized, though studies have shown no differences between these and placebo braces.11,28,29

Non-steroidal anti-inflammatory drugs and cryotherapy may also be considered for treatment of pain. Topical treatments such as menthol and diclofenac can serve as alternatives, as these medications have minimal systemic absorption. Transcutaneous nerve stimulation (TENS), ultrasound, phonophoresis, iontophoresis, extracorporeal shock wave therapy (ESWT), acupuncture, and dry needling may be beneficial as well.28,30,31,45 Glyceryl trinitrate patch therapy has been shown to decrease activity-related pain and to enhance healing, but have potential side effects such as headaches or flushing.28,32,33 Corticosteroid injections may give temporary partial pain relief, but their use is controversial due to their long-term tenotoxic effects and increased risk of injury recurrence.34 Botulinum toxin A injections may also provide relief for up to 16 weeks, but appear to be less effective than corticosteroid injections.27

After successful pain control, physical therapy should be initiated. This often begins with passive stretching of the wrist extensors, followed by progressive resistance training. Strengthening is initially done with isometric exercise, later advancing to concentric and eccentric exercises.35,36 There is reliable evidence to support that eccentric wrist extension exercises are effective.36

Patients with refractory symptoms of LE, despite conservative measures, can be considered for ultrasound-guided interventions and orthobiologic treatments. Current options include ultrasound-guided tenotomy, percutaneous ultrasonic tenotomy, prolotherapy, platelet rich plasma (PRP), and mesenchymal stem cells (MSCs).38 Recent literature suggests that PRP and percutaneous ultrasonic tenotomy can provide significant long-term benefits when compared to conservative therapy and other injections, with decreased complication rates (mainly being temporary pain after injection) with leukocyte-poor PRP as compared to leukocyte-rich PRP.37  A recent pilot study performed injections of adipose-derived stromal cells (ASCs) and noted significant clinical improvement and structural repair on MRI.43 Surgery can be considered for patients with persistent pain and disability that have not responded to appropriate nonoperative management after 6 to 12 months. The available surgical options include open, arthroscopic, and percutaneous approaches; there have not been significant differences in recovery shown between these options.18

Coordination of care

Patients with chronic LE causing sustained disability may require interdisciplinary treatments which incorporate physical and occupational therapies for strengthening and secondary prevention of LE. Vocational and rehabilitation psychologists should educate patients with LE regarding career modifications and integration into the community. In cases of tendon tear or rupture, recalcitrant LE, or radial nerve involvement, a surgical consultation may be necessary.

Patient & family education

Patients’ family and societal roles may change due to functional impairments. In chronic cases, helping patients reestablish their roles within the family using active rehabilitation exercises is important for optimal outcomes.

Translation into practice: practice “pearls”/performance improvement in practice (PIPs)/changes in clinical practice behaviors and skills

For treatment of LE, physicians should learn to integrate both traditional and modern techniques into their practices. Modern techniques include the use of musculoskeletal ultrasound for diagnostic and therapeutic purposes. Knowledge of how to differentiate LE vs. PIN compression vs. RTS based on clinical history and physical exam is important. Assessment for a concurrent RCL or LUCL injury with ultrasound or MRI can be helpful to predict those that may have a worse outcome with non-operative treatment. Understanding the underlying pathophysiology of LE and optimal conditions for healing, including tendon load, can assist in determining non-operative treatments to meet patient goals.

Cutting Edge/Emerging and Unique Concepts and Practice

Ultrasound-guided interventions and orthobiologics are emergent treatments directed at restoring normal tendon anatomy and function.29,39 Additional studies are still needed to establish the efficacy of these treatments. Ultrasound elastography (UE) is now being used to assess tendon stiffness and improve tendon health characterization. UE has shown early promise in improved diagnostic accuracy, prediction of at-risk tendons, and prognostication capability beyond conventional grey-scale US for tendinopathies.40

Gaps in the Evidence-Based Knowledge

Growing evidence suggests that PRP injections have long-term benefits, but there is still variability among practitioners regarding optimal formulation and injection technique.39,41,42,44 Additionally, post-PRP injection and ultrasound-guided intervention rehabilitation regimens are needed. Further studies should be performed in a homogeneous and larger patient population to establish which newly developed treatments are most effective. The eventual goal is to have a non-operative treatment algorithm based on the stage of the underlying pathology and mechanism of action of these treatments to provide individualized and targeted management.  

References

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Original Version of the Topic

Matthew Dounel, MD MPH, Kevin Pak, MD. Epicondylosis (Lateral) With and Without Nerve Entrapment. 9/19/2012.

Previous Revision(s) of the Topic

Jennifer Yang, MD, Nicholas Elkins, DO. Epicondylosis (Lateral) With and Without Nerve Entrapment. 9/14/2016.

Christian Roehmer, MD, Stephen Schaaf, MD. Epicondylosis (Lateral) With and Without Nerve Entrapment. 12/22/2020

Author Disclosure

Yolanda Pham, MD, MPH
Nothing to Disclose

Kevin Zheng, MD
Nothing to Disclose

Derek Ho, DO
Nothing to Disclose