Disease/Disorder Definition Endocrine abnormalities cause a wide variety of end-organ changes secondary to imbalances of normal hormonal homeostasis. Endocrine disease affecting the musculoskeletal system that will be covered in this section includes hypogonadism, hypopituitarism/growth hormone insufficiency, hypothyroidism/hyperthyroidism, and hyperadrenalism/hypoadrenalism. Additional … Continue reading Endocrine Abnormalities Affecting the Musculoskeletal System